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Research studies have emerged recently on the effect of sex hormones in COVID-19 patients, with a particular focus on estrogen. While most research in the past has primarily looked at the impact of estrogen on women, recent studies have explored its potential in helping men survive COVID-19.

Can Estrogen Help Men Combat COVID-19?

Estrogen is a hormone that is primarily associated with female reproductive health. However, both males and females have estrogen in their bodies, with males having a lower amount compared to females. Estrogen has been found to have anti-inflammatory properties, which can explain why it might help in fighting COVID-19.

According to a study published in The Lancet, estrogen may help men by reducing the severity of the virus and minimizing the risk of hospitalization. The study analyzed data from men and women across multiple countries and found that women tended to have fewer COVID-19 complications and were less likely to require hospitalization than men.

Interestingly, men who had undergone sex-change surgery and were receiving estrogen treatment did not exhibit the same high rates of COVID-19 complications as other men. This further suggests that estrogen may play a beneficial role in COVID-19 treatment.

Other Sex Hormones and Their Potential Role

While estrogen has taken center stage in COVID-19 research, other sex hormones such as progesterone and testosterone have also been considered. Progesterone, another female hormone, has been found to have anti-inflammatory properties similar to estrogen. According to another study published in JAMA, male patients with COVID-19 who were treated with progesterone had a reduced need for oxygen therapy and a lower risk of invasive mechanical ventilation compared to those who were not treated with progesterone.

Testosterone, on the other hand, has been linked to increased inflammation and a weaker immune response. This means that men with naturally high levels of testosterone may be more susceptible to COVID-19 complications. According to a study published in The Journal of Clinical Endocrinology & Metabolism, men with testosterone deficiency who were treated with testosterone showed improved lung function and reduced inflammation, suggesting that testosterone therapy may benefit men with COVID-19.

Conclusion

The research on sex hormones and COVID-19 is still in the early stages and more studies are needed to fully understand their potential therapeutic applications. However, the preliminary results suggest that estrogen, progesterone, and testosterone may play a role in COVID-19 treatment, particularly for male patients. It is important to note that hormone therapy should only be considered under the guidance of a medical professional and not as a self-treatment measure.

Figure 1:

Picture showing the link between estrogen and COVID-19.

Figure 2:

Picture showing the potential of progesterone in COVID-19 treatment.

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